PI 3-Kinase C2 beta Products

Description

PIK3C2B is encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner.

Bioinformatics

Entrez	5287 Human
Uniprot	NP_002637 Human O00750 Human
Product By Gene ID	5287
Alternate Names	C2-PI3KDKFZp686G16234 EC 2.7.1 EC 2.7.1.154 phosphatidylinositol 3-kinase C2 domain-containing beta polypeptide phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit beta Phosphoinositide 3-kinase-C2-beta phosphoinositide-3-kinase, class 2, beta polypeptide PI3K-C2beta PI3K-C2-beta PTDINS-3-kinase C2 beta PtdIns-3-kinase C2 subunit beta