PHD4/HIF Prolyl Hydroxylase 4 Products

Antibodies
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 Anti...
NB100-295
Species: Hu, Rt, Mu(-)
Applications: WB, EM, ICC/IF, IHC-P
Host: Rabbit Polyclonal
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 Anti...
NBP1-83989
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 Anti...
46020002
Species: Hu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Lysates
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 Over...
H00054681-T01
Species: Hu
Applications: WB
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 Over...
NBL1-14344
Applications: WB
Proteins
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 Reco...
H00054681-P01
Species: Hu
Applications: WB, ELISA, PA
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 Reco...
NBP1-83989PEP
Species: Hu
Applications: AC
RNAi
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 RNAi
H00054681-R02
Species: Hu
Applications: RNAi, RNAi SP
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 RNAi
H00054681-R01
Species: Hu
Applications: RNAi, RNAi SP
PHD4/HIF Prolyl Hydroxylase 4 ...
PHD4/HIF Prolyl Hydroxylase 4 RNAi
H00054681-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

Prolyl hydroxylase 4 is a prolyl hydroxylase that modifies HIF-alpha. Classic prolyl hydroxylases are found in the endoplasmic reticulum and modify collagen, whereas HIF is an intracellular protein and the prolyl hydroxylase sites do not resemble those modifying collagen. HIF is a transcriptional complex that plays a critical role in oxygen homeostasis. Prolyl hydroxylase is an essential component of the pathway through which cells sense oxygen. In the presence of oxygen, prolyl hydroxylases convert specific prolyl residues in HIF-alpha to hydroxyproline, leading to HIF-alpha destruction. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF is stable and there is increased angiogenesis. Prolyl hydroxylase 4, specifically, catalyzes the post-translational formation of 4-hydroxyproline in HIF alpha proteins. It may function as a cellular oxygen sensor and, under normoxic conditions, may targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 54681
Alternate Names
  • HPH-4
  • EC 1.14.11.-
  • HIF-PH4
  • transmembrane prolyl 4-hydroxylase
  • Hypoxia-inducible factor prolyl hydroxylase 4
  • Prolyl hydroxlase domain-containing 4
  • PHD4
  • proline 4-hydroxylase
  • PH-4
  • P4H with transmembrane domain
  • HIFPH4
  • hypoxia-inducible factor prolyl 4-hydroxylase
  • EGLN4
  • PH4 hypoxia inducible factor prolyl 4 hydroxylase
  • P4H-TMFLJ20262
  • HIF-prolyl hydroxylase 4
  • prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

Diseases related to PHD4/HIF Prolyl Hydroxylase 4

Discover more about diseases related to PHD4/HIF Prolyl Hydroxylase 4.

Rhabdomyosarcoma, Embryonal
Cell Transformation, Neoplastic
Alveolar Rhabdomyosarcoma
Childhood Rhabdomyosarcoma
Neoplasms
Rhabdomyosarcoma
Cytogenetic Abnormality
Sarcoma

Pathways for PHD4/HIF Prolyl Hydroxylase 4

View related products by pathway and learn more about each of the pathways below.

Methylation
Tissue Development
Dna Hypermethylation
Dna Methylation
Pathogenesis
Oncogenesis

Research Areas for PHD4/HIF Prolyl Hydroxylase 4

Find related products by research area and learn more about each of the different research areas below.

Cancer
Hypoxia
Lipid and Metabolism

PTMs for PHD4/HIF Prolyl Hydroxylase 4

Learn more about PTMs related to PHD4/HIF Prolyl Hydroxylase 4.

Methylation

Bioinformatics Tool for PHD4/HIF Prolyl Hydroxylase 4

Discover related pathways, diseases and genes to PHD4/HIF Prolyl Hydroxylase 4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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