PGLYRP1/PGRP-S Products

Description

The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Ib) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4). PGRP-S is present in neutrophils and inhibits growth of Gram-positive bacteria and, therefore, may function as a neutrophil antibacterial protein (5). However, PGRP-S may have another, as yet unidentified function because in humans it is expressed in the bone marrow 50

Bioinformatics

Uniprot	NM_005091 Human NP_005082 Human NP_005082.1 Human O75594 Human
Product By Gene ID	8993
Alternate Names	peptidoglycan recognition protein 1 Peptidoglycan recognition protein short PGLYRP PGRPpeptidoglycan recognition protein PGRP-SMGC126894 PGRPSMGC126896 TAG7 TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein) TNFSF3L