PCBD2 Products

Description

PCBD2, also known as Pterin-4-alpha-carbinolamine dehydratase 2, is a 130 amino acid protein that is 14 kDa, involved in tetrahydrobiopterin biosynthesis preventing the formation of 7-pterins and accelerating the formation of quinonoid-BH2, also being known to regulate the dimerization of homeodomain protein HNF-1-alpha and enhances its transcriptional activity. The protein is being studied for its involvement in hyperphenylalaninemia. The PCBD2 has also been shown to have interactions with DYRK1B, AATF, ASCC2, C1D, and CHAF1A in pathways such as phenylalanine degradation I (aerobic) pathway.

Bioinformatics

Uniprot	NM_032151 Human Q9H0N5 Human
Product By Gene ID	84105
Alternate Names	4-alpha-hydroxy-tetrahydropterin dehydratase 2 DCOH2DCOHMPHS2,6-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocytenuclear factor 1 alpha (TCF1) 2 DcoH-like protein DCoHm dimerization cofactor of hepatocyte nuclear factor 1 (HNF1) from muscle dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) Dimerization cofactor of hepatocyte nuclear factor 1 from muscle EC 4.2.1.96 HNF-1-alpha dimerization cofactor PHS 2 pterin-4 alpha-carbinolamine dehydratase 2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocytenuclear factor 1 alpha (TCF1) 2 pterin-4-alpha-carbinolamine dehydratase 2