Species: Hu, Mu, Rt
Applications: WB, ICC
Host: Mouse Monoclonal
Hu, Mu, Rt, Ch, Bv, Ch, SyHa, ZeApplications:
WB, Simple Western, ICC/IF, In vitro, IPHost:
Hu, Mu, Rt, PmApplications:
WB, ICC/IF, IHC, IHC-P, IPHost:
Applications: RNAi, RNAi SP
PARK7, also known as DJ-1, is a member of the peptidase C56 protein family. The PARK-7 protein is a positive regulator of androgen receptor-dependent transcription. It has also been reported to be a potential sensor for oxidative stress, a redox-sensitive chaperone, and a key protein for preventing neuronal oxidative stress and cell death.
PARK7 is highly expressed in pancreas, kidney, skeletal muscle, liver, testis and heart, and is detected at slightly lower levels in placenta and brain. The protein is also detected in astrocytes, Sertoli cells, spermatogonia, spermatids and spermatozoa.
Defects in this gene cause the autosomal recessive neurodegenerative disorder early-onset Parkinson's disease 7.