OS9 Products

Antibodies
OS9 Antibody
OS9 Antibody
BC100-520
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF
Host: Rabbit Polyclonal
OS9 Antibody
OS9 Antibody
NBP1-84803
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
OS9 Overexpression Lysate (Na ...
OS9 Overexpression Lysate (Native)
NBP2-08681
Applications: WB
OS9 Overexpression Lysate (Na ...
OS9 Overexpression Lysate (Native)
NBL1-13982
Applications: WB
OS9 Overexpression Lysate (De ...
OS9 Overexpression Lysate (Denatured)
H00010956-T01
Applications: WB
Proteins
OS9 Peptide
OS9 Peptide
BC100-520PEP
Species: Hu
OS9 Peptide
OS9 Peptide
NB100-519PEP
Species: Hu
OS9 Recombinant Protein
OS9 Recombinant Protein
H00010956-P01
Species: Hu
Applications: WB, ELISA, PA

Description

OS9 is a lectin which functions in endoplasmic reticulum quality control and ER-associated degradation. This ER glycoprotein is found in the intralumenal level and highly expressed in tumor tissue. The OS9 gene is transcriptionally induced upon activation of the Ire1/Xbp1 ER-stress pathway.

Functionally, OS9 binds to HIF-1, a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. It may also bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. One such possible target includes TRPV4.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 10956
Alternate Names
  • protein OS-9
  • Amplified in osteosarcoma 9
  • osteosarcoma amplified 9, endoplasmic reticulum associated protein
  • OS-9
  • erlectin 2
  • ERLEC2
  • endoplasmic reticulum lectin 2
  • osteosarcoma amplified 9, endoplasmic reticulum lectin

Research Areas for OS9

Find related products by research area and learn more about each of the different research areas below.

Cancer
Chromatin Research
Hypoxia
Immunology

PTMs for OS9

Learn more about PTMs related to OS9.

Glycosylation
Ubiquitination
Phosphorylation
Biotinylation
Hydroxylation

Bioinformatics Tool for OS9

Discover related pathways, diseases and genes to OS9. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related OS9 Blog Posts

Check out the latest blog posts on OS9.
OS9: Taking proteins to the ER finish line
The OS9 protein is a lectin/glycoprotein that maintains endoplasmic reticulum (ER) quality control and ER-associated degradation (the so-called ERAD pathway) of newly synthesized proteins. It is essential for the recognition of terminally misfolded no...    Read more.
Read more OS9 related blogs.