ORP150/HSP12A Products

Description

HYOU1 is encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment is found at the 5' end of the first exon, and is involved in stress-dependent induction. A transcript that is produced from a downstream start site is preferentially induced by hypoxia, resulting in the accumulation of this protein in the endoplasmic reticulum (ER). The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol.

Bioinformatics

Entrez	10525 Human 12282 Mouse 192235 Rat
Uniprot	AAH04560 Human AAH04560.1 Human AAH72436.1 Human NP_006380 Human Q9Y4L1 Human
Product By Gene ID	10525
Alternate Names	150 kDa oxygen-regulated protein 170 kDa glucose-regulated protein DKFZp686N08236 FLJ97572 glucose-regulated protein 170 Grp170 GRP170 GRP-170 HSP12A hypoxia up-regulated 1 hypoxia up-regulated protein 1 ORP-150 ORP150FLJ94899 oxygen regulated protein (150kD)

Research Areas for ORP150/HSP12A

Find related products by research area and learn more about each of the different research areas below.

Hypoxia