NUDT2 Products

Description

NUDT2 encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and three transcript variants, all encoding the same protein, have been identified.

Bioinformatics

Uniprot	AAH04926 Human NM_001161 Human NM_147173 Human NP_001152 Human NP_001152.1 Human NP_671701 Human NP_671702 Human
Product By Gene ID	318
Alternate Names	Ap4A hydrolase 1 Ap4A hydrolase Ap4Aase APAH1Diadenosine 5'-5'''-P1 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] diadenosine 5'-5''-P1 Diadenosine tetraphosphatase EC 3.6.1.17 MGC10404 Nucleoside diphosphate-linked moiety X motif 2 nudix (nucleoside diphosphate linked moiety X)-type motif 2 Nudix motif 2 P4-tetraphosphate asymmetrical hydrolase P4-tetraphosphate pyrophosphohydrolase

Research Areas for NUDT2

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Angiogenesis
Apoptosis