Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Mouse monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP). In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and -H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nucleasehypersensitive elements at positions 142 to 115 of the human c-Myc promotor.
Bioinformatics
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
4830 |
| Alternate Names |
- EC 2.7.4.6
- GAAD
- Granzyme A-activated DNase
- Metastasis inhibition factor nm23
- NB
- NBS
- NDK A
- NDKA
- NDP kinase A
- NDPKA
- NDPK-A
- NM23AWD
- NM23-H1
- nm23-H1
- non-metastatic cells 1, protein (NM23A) expressed in
- nucleoside diphosphate kinase A
- Tumor metastatic process-associated protein
|
Research Areas for NM23-H1
Find related products by research area and learn more about each of the different research areas below.
Lipid and Metabolism
![Enzyme Activity NM23-H1 [Unconjugated]](http://images.novusbio.com/fullsize2/NM23H1_10495NM_3250.jpg)
![SDS-PAGE NM23-H1 [Unconjugated]](http://images.novusbio.com/fullsize2/10495-nm_recombinant-human-nm23-h1-his-tag-protein-cf-sds-page-21102022104814.jpg)