NM23-H1 Products

Description

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq]

Bioinformatics

Entrez	4830 Human
Uniprot	AAH00293 Human
Product By Gene ID	4830
Alternate Names	EC 2.7.4.6 GAAD Granzyme A-activated DNase Metastasis inhibition factor nm23 NB NBS NDK A NDKA NDP kinase A NDPKA NDPK-A NM23A NM23AWD NM23H1 NM23-H1 NME1 non-metastatic cells 1, protein (NM23A) expressed in nucleoside diphosphate kinase A Tumor metastatic process-associated protein

Research Areas for NM23-H1

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Lipid and Metabolism