NLRP1/NALP1 Products

Antibodies
NLRP1/NALP1 Antibody
NLRP1/NALP1 Antibody
NBP1-54899
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-Fr
Host: Rabbit Polyclonal
NLRP1/NALP1 Antibody
NLRP1/NALP1 Antibody
NB100-56148
Species: Hu
Applications: WB, IHC, IHC-Fr, IHC-P, IP
Host: Rabbit Polyclonal
NLRP1/NALP1 Antibody
NLRP1/NALP1 Antibody
NB100-56147
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Lysates
NLRP1/NALP1 Overexpression Ly ...
NLRP1/NALP1 Overexpression Lysate ...
NBL1-13671
Applications: WB
NLRP1/NALP1 Overexpression Ly ...
NLRP1/NALP1 Overexpression Lysate ...
H00022861-T01
Species: Hu
Applications: WB
Proteins
NLRP1/NALP1 Blocking Peptide
NLRP1/NALP1 Blocking Peptide
NBP1-76656PEP
Species: Hu
Applications: AC
NLRP1/NALP1 Recombinant Prote ...
NLRP1/NALP1 Recombinant Protein An...
NBP2-57196PEP
Species: Hu
Applications: AC

Description

NALP1 (also known as NAC/CARD7) is a member of the CATERPILLER (CLR) diverse multigene superfamily of immune regulatory proteins (Ting and Davis, 2005). CLR proteins have a variable N-terminal domain, followed by a nucleotide-binding domain (NBD) and leucine-rich repeats (LRR). The N-terminal domain consists of transactivation, CARD, Pyrin or BIR domains, or in some cases is undefined. The CLR family, also known as the NOD family, has its ancient roots in the plant kingdom and is related to the disease resistance (R) gene family that mediates plant immune responses. CLR proteins participate in both innate and adaptive immunity in mammals, some act as sensors that detect pathogen products, and several CLR genes have been linked to susceptibility to immunological diseases. It is thought that the CLR family may have a fundamental importance for the function of the mammalian innate/ancient immune system on par with the Toll-like receptor (TLR) family. NALP1, a member of NALP CLR subfamily, has an N-terminal pyrin domain (PYD), followed by an NBD, LRR, and a C-terminal CARD domain (reviewed in Tschopp. NALP1 is a component of both the inflammasome and apoptosome, suggesting that NALP1 it has important roles in both inflammation and apoptosis. This antibody recognizes NALP1; human NALP1 is a 1473 amino acid protein and migrates at approx. 166 kDa on SDS-PAGE. However, multiple splice variants encoding distinct NALP1 isoforms with varying amino acid lengths have been described and thus the molecular weight detected may vary depending on the isoform(s) expressed.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Product By Gene ID 22861
Alternate Names
  • Death effector filament-forming ced-4-like apoptosis protein
  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domaincontaining 1
  • Caspase recruitment domain-containing protein 7
  • NACHT, LRR and PYD domains-containing protein 1
  • NACHT, leucine rich repeat and PYD (pyrin domain) containing 1
  • NACHT, LRR and PYD containing protein 1
  • DKFZp586O1822
  • NACHT, leucine rich repeat and PYD containing 1
  • CLR17.1
  • NALP1caspase recruitment domain protein 7
  • NACPP1044
  • KIAA0926DEFCAP-L/S
  • DEFCAPVAMAS1
  • CARD7SLEV1
  • Nucleotide-binding domain and caspase recruitment domain
  • NLR family, pyrin domain containing 1

Research Areas for NLRP1/NALP1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis

PTMs for NLRP1/NALP1

Learn more about PTMs related to NLRP1/NALP1.

Cleavage
Phosphorylation

Bioinformatics Tool for NLRP1/NALP1

Discover related pathways, diseases and genes to NLRP1/NALP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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