Niemann-Pick C1 Products

Antibodies
Proteins
Niemann-Pick C1 Blocking Pept ...
Niemann-Pick C1 Blocking Peptide
NB400-148PEP
Species: Hu
Recombinant Human Niemann-Pic ...
Recombinant Human Niemann-Pick C1 ...
H00004864-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Niemann-Pick C1 RNAi
Niemann-Pick C1 RNAi
H00004864-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Niemann-Pick type C1 (NPC1) is a member of a family of genes encoding membrane-bound proteins containing putative sterol sensing domains. The protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. NPC1 overexpression increases both the rate of trafficking of low density lipoprotein cholesterol to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma membrane. NPC disease is an inherited neurovisceral lipid storage disorder of unesterified cholesterol accumulation in lysosomes. It is characterized by progressive neural and liver degeneration, resulting from inactivating mutations in NPC1, in most cases.

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 4864
Alternate Names
  • NPC1
  • Niemann-Pick C1 protein
  • FLJ98532
  • NPC
  • Niemann-Pick disease, type C1

Research Areas for Niemann-Pick C1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cholesterol Metabolism
Lipid and Metabolism
Membrane Trafficking and Chaperones
Neurodegeneration
Neuronal Cell Markers
Neuroscience
Neurotransmission
Signal Transduction

Bioinformatics Tool for Niemann-Pick C1

Discover related pathways, diseases and genes to Niemann-Pick C1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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