Nicotinic Acetylcholine R alpha 7/CHRNA7 Products

Antibodies
Nicotinic Acetylcholine R alp ...
Nicotinic Acetylcholine R alpha 7/...
NBP1-52375
Species: Hu, Mu, Rt, Po, Bv, Ca, Ch, Eq, Mk, Ha, Op, Rb
Applications: ELISA, IHC-P
Host: Goat Polyclonal
Nicotinic Acetylcholine R alp ...
Nicotinic Acetylcholine R alpha 7/...
NBP1-79948
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Nicotinic Acetylcholine R alp ...
Nicotinic Acetylcholine R alpha 7/...
NBP1-80092
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Lysates
Proteins
Recombinant Human Nicotinic A ...
Recombinant Human Nicotinic Acetyl...
H00001139-P01
Species: Hu
Applications: WB, ELISA, PA
RNAi
Nicotinic Acetylcholine R alp ...
Nicotinic Acetylcholine R alpha 7/...
H00001139-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediatefast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits.The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conservedtransmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminalextracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeabilityto calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to,alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation thataffects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene islocated in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomallocation involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event inthis region results in a hybrid containing sequence from this gene and a novel FAM7A gene. (provided by RefSeq)

Bioinformatics

Uniprot Human
Human
Human
Product By Gene ID 1139
Alternate Names
  • a7 nicotinic acetylcholine receptor
  • neuronal acetylcholine receptor subunit alpha-7
  • CHRNA7-2
  • neuronal acetylcholine receptor protein, alpha-7 chain
  • NACHRA7
  • alpha-7 nicotinic cholinergic receptor subunit
  • cholinergic receptor, nicotinic, alpha polypeptide 7
  • alpha 7 neuronal nicotinic acetylcholine receptor
  • cholinergic receptor, nicotinic, alpha 7

PTMs for Nicotinic Acetylcholine R alpha 7/CHRNA7

Learn more about PTMs related to Nicotinic Acetylcholine R alpha 7/CHRNA7.

Methylation
Phosphorylation

Bioinformatics Tool for Nicotinic Acetylcholine R alpha 7/CHRNA7

Discover related pathways, diseases and genes to Nicotinic Acetylcholine R alpha 7/CHRNA7. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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