Neurocan Products

Description

Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain. It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development. Neurocan expression in the brain is developmentally regulated. Early on the major form of Neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each. Later Neurocan comprises a 180kD core protein Both forms of Neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains. By virtue of their high expression at sites of neural damage and trauma, chondroitin sulfate proteoglycans, including Neurocan, are thought to inhibit successful nerve regeneration.

Bioinformatics

Uniprot	NP_004377 Human
Product By Gene ID	1463
Alternate Names	chondroitin sulfate proteoglycan 3 (neurocan) Chondroitin sulfate proteoglycan 3 CSPG3neurocan core protein FLJ44681 NEUR neurocan proteoglycan neurocan