Neuregulin-3/NRG3 Products

Description

NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Bioinformatics

Uniprot	NP_001010848 Human NP_001010848.2 Human P56975 Human P56975-4 Human
Product By Gene ID	10718
Alternate Names	HRG3 neuregulin 3 variant 1 neuregulin 3 variant 10 neuregulin 3 variant 11 neuregulin 3 variant 12 neuregulin 3 variant 13 neuregulin 3 variant 14 neuregulin 3 variant 3 neuregulin 3 variant 4 neuregulin 3 variant 5 neuregulin 3 variant 6 neuregulin 3 variant 7 neuregulin 3 variant 8 neuregulin 3 variant 9 neuregulin 3 neuregulin-3-like polypeptide pro-neuregulin-3, membrane-bound isoform Pro-NRG3 pro-NRG3