NCOA3/AIB1 Products

Antibodies
NCOA3/AIB1 Antibody
NCOA3/AIB1 Antibody
NB100-314
Species: Hu
Applications: WB, IP, PLA
Host: Rabbit Polyclonal
NCOA3/AIB1 Antibody
NCOA3/AIB1 Antibody
NBP1-90256
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
NCOA3/AIB1 Overexpression Lys ...
NCOA3/AIB1 Overexpression Lysate (...
NBL1-13517
Applications: WB
Proteins
NCOA3/AIB1 Partial Recombinan ...
NCOA3/AIB1 Partial Recombinant Pro...
H00008202-Q01
Species: Hu
Applications: WB, ELISA, PA
NCOA3/AIB1 Recombinant Protei ...
NCOA3/AIB1 Recombinant Protein Ant...
NBP1-90256PEP
Species: Hu
Applications: AC
RNAi
NCOA3/AIB1 RNAi
NCOA3/AIB1 RNAi
H00008202-R01
Species: Hu
Applications: RNAi, RNAi SP
NCOA3/AIB1 RNAi
NCOA3/AIB1 RNAi
H00008202-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

NCOA3/SRC3 (nuclear receptor coactivator 3/steroid receptor coactivator 3 (SRC3)) is a 155 kD member of the p160/steroid receptor coactivator family containing a nuclear localization sequence, bHLH, and PAS domain. There are two reported isoforms of this protein. NCOA3/SRC3 is localized mainly in the cytoplasm, with weak nuclear expression. The protein is translocated to the nucleus upon phosphorylation. NCOA3/SRC3 is widely expressed with high expression in the heart, skeletal muscle, pancreas, and placenta and low expression in the brain. NCOA3/SRC3 is expressed at very low levels in the lung, liver, and kidney and overexpressed in breast and ovarian cancers. This protein has histone acetyltransferase activity and functions as a transcriptional coactivator for steroid and nuclear hormone receptors. Phosphorylation by I kappaB kinase enhances coactivator function. Acetylation by CREB-BP disrupts interaction with nuclear receptors. NCOA3/SRC3 forms a multisubunit coactivation complex with NCOA2 IKKA, IKKB, IKBKG and histone acetyltransferase protein CREB binding protein and has also been shown to interact with PCAF.

Bioinformatics

Entrez Human
Human
Uniprot Human
Human
Human
Human
Product By Gene ID 8202
Alternate Names
  • pCIP
  • Steroid receptor coactivator protein 3
  • TRAM1
  • Receptor-associated coactivator 3
  • RAC-3
  • Class E basic helix-loop-helix protein 42
  • NCoA-3
  • Amplified in breast cancer 1 protein
  • BHLHE42
  • TNRC16
  • SRC3
  • MGC141848
  • KAT13B
  • CTG26
  • CAGH16
  • bHLHe42p/CIP
  • TRAM-1TNRC14
  • SRC-3EC 2.3.1.48
  • RAC3pCIP
  • ACTRCBP-interacting protein
  • AIB1AIB-1
  • Thyroid hormone receptor activator molecule 1
  • nuclear receptor coactivator 3

Research Areas for NCOA3/AIB1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cancer
Chromatin Research
Transcription Factors and Regulators

PTMs for NCOA3/AIB1

Learn more about PTMs related to NCOA3/AIB1.

Phosphorylation
Acetylation
Methylation
Ubiquitination
Sumoylation
Biotinylation
Dephosphorylation

Bioinformatics Tool for NCOA3/AIB1

Discover related pathways, diseases and genes to NCOA3/AIB1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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