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MMP-1 Products

Antibodies
MMP-1 Antibody (36665) [Uncon ...
MMP-1 Antibody (36665) [Unconjugated]
Species: Hu
Applications: WB, IHC, IP, B/N, KO
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
MMP-1 Antibody [Unconjugated] ...
MMP-1 Antibody [Unconjugated]
AF901
Species: Hu
Applications: WB, IHC, ELISA(Cap), KO
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
ELISA Kits
Human Pro-MMP-1 Quantikine EL ...
Human Pro-MMP-1 Quantikine ELISA Kit
DMP100
Species: Hu
Applications: ELISA
Conjugate Catalog # Availability Size Price
Human Pro-MMP-1 DuoSet ELISA, ...
Human Pro-MMP-1 DuoSet ELISA, 5 Plate
DY900-05
Species: Hu
Applications: ELISA
Rabbit MMP-1 ELISA Kit (Color ...
Rabbit MMP-1 ELISA Kit (Colorimetric)
NBP3-06899
Species: Rb
Applications: ELISA
Lysates
MMP-1 Overexpression Lysate
MMP-1 Overexpression Lysate
NBL1-13149
Species: Hu
Applications: WB
Proteins
Recombinant Human MMP-1 Prote ...
Recombinant Human MMP-1 Protein, CF
901-MP
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
Recombinant Human MMP-1 Weste ...
Recombinant Human MMP-1 Western Bl...
WBC024
Species: Hu
Applications: WB
Recombinant Human MMP-1 His P ...
Recombinant Human MMP-1 His Protein
NBP2-52617
Species: Hu
Applications: PAGE

Description

Human interstitial collagenase (matrix metalloproteinase-1, MMP-1), an enzyme whose only known physiologic substrate has heretofore been believed to be the extracellular matrix molecule, collagen. Data indicate that matrix metalloproteinase-1 displays an expanded substrate repertoire that supports the existence of a new interface between connective tissue turnover and serine proteinase inhibitors (1). It has been shown that the MMP-1 functions as a protease agonist of Protease-activated receptors (PAR1) cleaving the receptor at the proper site to generate PAR1-dependent Ca2+ signals and migration. These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion (2). It has also been suggested that increased levels of MMP-1 due to tobacco smoking plays a major role in the aging process of skin since MMP-1 degrades collagen, which accounts for at least 70% of the dry weight of dermis. Significantly more MMP-1 has been detected in the skin of smokers than non-smokers whereas no difference was seen for the tissue inhibitor of metalloproteinases 1 (3).

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 4312
Alternate Names
  • CLGmatrix metalloprotease 1
  • CLGN
  • EC 3.4.24
  • EC 3.4.24.7
  • Fibroblast collagenase
  • interstitial collagenase
  • matrix metallopeptidase 1 (interstitial collagenase)
  • matrix metalloproteinase 1 (interstitial collagenase)
  • Matrix metalloproteinase-1
  • MMP-1

Research Areas for MMP-1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Cellular Markers
Cytoskeleton Markers
Extracellular Matrix