MMP-1 Products

Antibodies
MMP-1 Antibody (36665R) [Unco ...
MMP-1 Antibody (36665R) [Unconjuga...
MAB901R
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
MMP-1 Antibody (40013F) [Unco ...
MMP-1 Antibody (40013F) [Unconjuga...
MAB9011
Species: Hu
Applications: WB
Host: Goat Monoclonal
MMP-1 Antibody (36665) [Uncon ...
MMP-1 Antibody (36665) [Unconjugated]
MAB901
Species: Hu
Applications: WB, IHC, IP, Neut
Host: Mouse Monoclonal
Antibody Pairs
MMP-1 Antibody Pair
MMP-1 Antibody Pair
H00004312-PW1
Species: Hu
Applications: WB, IP
ELISA Kits
Lysates
MMP-1 Overexpression Lysate ( ...
MMP-1 Overexpression Lysate (Denat...
H00004312-T01
Species: Hu
Applications: WB
MMP-1 Overexpression Lysate ( ...
MMP-1 Overexpression Lysate (Native)
NBL1-13149
Applications: WB
Proteins
MMP-1 Recombinant Protein
MMP-1 Recombinant Protein
NBP2-51558
Species: Hu
Applications: PAGE
MMP-1 Recombinant Protein
MMP-1 Recombinant Protein
NBP2-52617
Species: Hu
Applications: PAGE
MMP-1 Recombinant Protein
MMP-1 Recombinant Protein
NBP1-99536
Species: Hu
RNAi
MMP-1 RNAi
MMP-1 RNAi
H00004312-R01
Species: Hu

Description

Human interstitial collagenase (matrix metalloproteinase-1, MMP-1), an enzyme whose only known physiologic substrate has heretofore been believed to be the extracellular matrix molecule, collagen. Data indicate that matrix metalloproteinase-1 displays an expanded substrate repertoire that supports the existence of a new interface between connective tissue turnover and serine proteinase inhibitors (1). It has been shown that the MMP-1 functions as a protease agonist of Protease-activated receptors (PAR1) cleaving the receptor at the proper site to generate PAR1-dependent Ca2+ signals and migration. These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion (2). It has also been suggested that increased levels of MMP-1 due to tobacco smoking plays a major role in the aging process of skin since MMP-1 degrades collagen, which accounts for at least 70% of the dry weight of dermis. Significantly more MMP-1 has been detected in the skin of smokers than non-smokers whereas no difference was seen for the tissue inhibitor of metalloproteinases 1 (3).

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 4312
Alternate Names
  • CLGN
  • EC 3.4.24
  • matrix metalloproteinase 1 (interstitial collagenase)
  • Matrix metalloproteinase-1
  • EC 3.4.24.7
  • MMP-1
  • Fibroblast collagenase
  • CLGmatrix metalloprotease 1
  • interstitial collagenase
  • matrix metallopeptidase 1 (interstitial collagenase)

Research Areas for MMP-1

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cell Biology
Cellular Markers
Cytoskeleton Markers
Extracellular Matrix

Bioinformatics Tool for MMP-1

Discover related pathways, diseases and genes to MMP-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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