MGMT Products

Antibodies
MGMT Antibody (MT 3.1)
MGMT Antibody (MT 3.1)
NB100-692
Species: Hu
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
MGMT Antibody (4F9)
MGMT Antibody (4F9)
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
Antibody Pairs
MGMT Antibody Pair
MGMT Antibody Pair
H00004255-PW1
Species: Hu
Applications: WB, IP
Lysates
MGMT Overexpression Lysate (N ...
MGMT Overexpression Lysate (Native)
NBP2-10226
Applications: WB
MGMT Overexpression Lysate (D ...
MGMT Overexpression Lysate (Denatu...
H00004255-T01
Applications: WB
Proteins
MGMT Recombinant Protein
MGMT Recombinant Protein
NBC1-18534
Species: Hu
Applications: PAGE
RNAi
MGMT RNAi
MGMT RNAi
H00004255-R01
Species: Hu

Description

O6-Methylguanine-DNA Methyltransferase (MGMT) is an important DNA repair protein involved in tumor cell resistance to the cytotoxic activity of chemotherapeutic alkylating agents. This protein is also effective in protecting normal cells against the genotoxic and carcinogenic effects of DNA alkylation. The alkylating drug resistance is caused by MGMT's ability to remove DNA alkyl groups introduced in the O6 position of guanine. MGMT is expressed in highly variable amounts, depending upon the cell and tissue type, species, and cellular growth characteristics. In addition, MGMT activity varies among groups of tumors and within a particular type of tumor.

MGMT antibodes are useful tools for DNA repair studies and for some cancer research.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 4255
Alternate Names
  • EC 2.1.1.63
  • O6-methylguanine-DNA methyltransferase
  • O-6-methylguanine-DNA-alkyltransferase
  • methylguanine-DNA methyltransferase
  • 6-O-methylguanine-DNA methyltransferase
  • methylated-DNA--protein-cysteine methyltransferase
  • O-6-methylguanine-DNA methyltransferase

Research Areas for MGMT

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Chromatin Research
Direct Reversal of DNA Damage
DNA Repair
Tumor Suppressors

Bioinformatics Tool for MGMT

Discover related pathways, diseases and genes to MGMT. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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