MED13 Products

Description

MED13 encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator.

Bioinformatics

Entrez	9969 Human
Uniprot	NP_005112.2 Human Q9UHV7 Human
Product By Gene ID	9969
Alternate Names	Activator-recruited cofactor 250 kDa component KIAA0593HSPC221 mediator complex subunit 13ARC250 mediator of RNA polymerase II transcription, subunit 13 homolog THRAP1mediator of RNA polymerase II transcription subunit 13 thyroid hormone receptor associated protein 1 Thyroid hormone receptor-associated protein 1 Thyroid hormone receptor-associated protein complex 240 kDa component thyroid hormone receptor-associated protein complex component TRAP240 thyroid hormone receptor-associated protein, 240 kDa subunit Trap240 TRAP240DRIP250 Vitamin D3 receptor-interacting protein complex component DRIP250