MCM7 Products

Description

The minichromosome maintenance (MCM7) helicase complex functions to initiate and elongate replication forks. Cell cycle checkpoint signaling pathways regulate DNA replication to maintain genomic stability (1). MCM7 is a putative human homologue of yeast CDC47 and a member of the MCM protein family, which has been implicated in the regulatory machinery causing DNA to replicate only once in the S phase. Findings indicate that MCM7 protein together with other MCM proteins participates in the regulation of mammalian DNA replication (2). In HeLa cells, depletion of MCM7 with small-interfering RNA suppressed ultraviolet (UV) light- or aphidicolin-induced hChk1 phosphorylation, and abolished UV-induced S-phase checkpoint activation. These results demonstrate that MCM7 plays a direct role in the transmission of DNA damage signals from active replication forks to the S-phase checkpoint machinery in human cells (3).

Bioinformatics

Product By Gene ID	4176
Alternate Names	CDC47 homolog CDC47 CDC47P85MCM DNA replication licensing factor MCM7 EC 3.6.4.12 homolog of S. cerevisiae Cdc47 MCM2 MCM2PNAS146 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) MCM7 minichromosome maintenance complex component 7 minichromosome maintenance deficient (S. cerevisiae) 7 minichromosome maintenance deficient 7 P1.1-MCM3 P1CDC47 P85MCM PNAS146 PPP1R104 Protein Phosphatase 1

Research Areas for MCM7

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Cellular Markers
Core ESC-Like Genes
DNA Repair
Stem Cell Markers