After August 17, 2026, Novus Biologicals products and services will no longer be available on this website; you will access all products and services on rndsystems.com. Create your R&D Systems online account today.
The minichromosome maintenance (MCM7) helicase complex functions to initiate and elongate replication forks. Cell cycle checkpoint signaling pathways regulate DNA replication to maintain genomic stability (1). MCM7 is a putative human homologue of yeast CDC47 and a member of the MCM protein family, which has been implicated in the regulatory machinery causing DNA to replicate only once in the S phase. Findings indicate that MCM7 protein together with other MCM proteins participates in the regulation of mammalian DNA replication (2). In HeLa cells, depletion of MCM7 with small-interfering RNA suppressed ultraviolet (UV) light- or aphidicolin-induced hChk1 phosphorylation, and abolished UV-induced S-phase checkpoint activation. These results demonstrate that MCM7 plays a direct role in the transmission of DNA damage signals from active replication forks to the S-phase checkpoint machinery in human cells (3).
![Western Blot MCM7 Antibody (2068B) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/MCM7_MAB9217_Western_Blot_20473.jpg)
![Immunocytochemistry MCM7 Antibody (2068B) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/MCM7_MAB9217_Immunocytochemistry__Immunofluorescence_20405.jpg)
![Immunohistochemistry MCM7 Antibody (2068B) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/MCM7_MAB9217_Immunohistochemistry_20404.jpg)
![Intracellular Staining by Flow Cytometry MCM7 Antibody (2068B) [Unconjugated]](http://images.novusbio.com/fullsize/antibody/MCM7_MAB9217_Flow_Cytometry_20411.jpg)
