Species: Hu
Applications: WB, ELISA, Func, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready, ICC/IF
Host: Rabbit Monoclonal
Species: Hu, Mu, Rt, Bv
Applications: WB, ICC/IF, IHC, IP, ChIP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: PAGE
Species: Hu
Applications: AC
Description
The minichromosome maintenance (MCM7) helicase complex functions to initiate and elongate replication forks. Cell cycle checkpoint signaling pathways regulate DNA replication to maintain genomic stability (1). MCM7 is a putative human homologue of yeast CDC47 and a member of the MCM protein family, which has been implicated in the regulatory machinery causing DNA to replicate only once in the S phase. Findings indicate that MCM7 protein together with other MCM proteins participates in the regulation of mammalian DNA replication (2). In HeLa cells, depletion of MCM7 with small-interfering RNA suppressed ultraviolet (UV) light- or aphidicolin-induced hChk1 phosphorylation, and abolished UV-induced S-phase checkpoint activation. These results demonstrate that MCM7 plays a direct role in the transmission of DNA damage signals from active replication forks to the S-phase checkpoint machinery in human cells (3).
Bioinformatics
| Entrez |
Mouse
Rat
Human
|
| Uniprot |
Human
Human
Human
Human
Human
Human
|
| Product By Gene ID |
4176 |
| Alternate Names |
- CDC47 homolog
- CDC47P85MCM
- DNA replication licensing factor MCM7
- EC 3.6.4.12
- homolog of S. cerevisiae Cdc47
- MCM2PNAS146
- MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
- minichromosome maintenance complex component 7
- minichromosome maintenance deficient (S. cerevisiae) 7
- minichromosome maintenance deficient 7
- P1.1-MCM3
- P1CDC47
|
