Species: Hu
Applications: WB, IHC, IP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, IHC, KO
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Hu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Species: Hu
Applications: PAGE, SPR
Description
Myeloid Cell Leukemia 1 (Mcl 1) is a member of a family of anti-apoptotic proteins related to Bcl-2 that include Bcl-2, Bcl-xL, Bcl-w, Bfl-1, BHRF-1 and CED-9. The Bcl-2 related family of proteins regulate apoptosis through the formation of both homo and heterodimers. Mcl 1 has been demonstrated to preferentially dimerize with the pro-apoptotic Bcl-2 family members which include Bax, Bak, Bok, Bik, and BOD. Rat and human Mcl 1 contain three Bcl-2 homology domains, denoted as BH1, BH2 and BH3, and is localized primarily to the mitochondria.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
4170 |
| Alternate Names |
- BCL2L3
- Bcl2-L-3
- BCL2L3MGC104264
- Bcl-2-like protein 3
- Bcl-2-related protein EAT/mcl1
- EAT
- induced myeloid leukemia cell differentiation protein Mcl-1
- Mcl1
- Mcl-1
- mcl1/EAT
- MCL1-ES
- MCL1L
- MCL1S
- MGC1839
- myeloid cell leukemia ES
- myeloid cell leukemia sequence 1 (BCL2-related)
- TM
|
Research Areas for Mcl-1
Find related products by research area and learn more about each of the different research areas below.
ApoptosisCancerTumor Suppressors
![Western Blot Mcl-1 Antibody (542808) [Unconjugated]](http://images.novusbio.com/fullsize2/Mcl-1_MAB828_Western_Blot_6290.jpg)
![Knockout Validated Mcl-1 Antibody (542808) [Unconjugated]](http://images.novusbio.com/fullsize2/Mcl1_MAB828_Knockout_Validated_22995.jpg)
