WB, IHC, IHC-P, IPHost:
WB, IHC, KOHost:
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Monoclonal
Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.
|Product By Gene ID
- myeloid cell leukemia ES
- induced myeloid leukemia cell differentiation protein Mcl-1
- Bcl-2-related protein EAT/mcl1
- Bcl-2-like protein 3
- myeloid cell leukemia sequence 1 (BCL2-related)
Bioinformatics Tool for Mcl-1
Discover related pathways, diseases and genes to Mcl-1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.