Species: Hu, Mu(-)
Applications: ICC/IF, IHC, WB (-)
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ChIP, ChIP
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: AC
Description
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq]
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
Human
|
| Product By Gene ID |
8930 |
| Alternate Names |
- EC 3.2.2.-
- G/T mismatch glycosylase
- G/U mismatch glycosylase
- MED1G/5-fluorouracil mismatch glycosylase with biphasic kinetics
- methyl-CpG binding domain protein 4
- methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylase
- Methyl-CpG-binding endonuclease 1
- Methyl-CpG-binding protein MBD4
- Mismatch-specific DNA N-glycosylase
- putative methyl-CpG binding protein
|
