MBD4 Products

Antibodies
MBD4 Antibody
MBD4 Antibody
NBP2-24393
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
MBD4 Antibody
MBD4 Antibody
AF5935
Species: Hu, Mu
Applications: WB
Host: Goat Polyclonal
Proteins
Recombinant Human MBD4 Protei ...
Recombinant Human MBD4 Protein
H00008930-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
MBD4 RNAi
MBD4 RNAi
H00008930-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq]

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 8930
Alternate Names
  • EC 3.2.2.-
  • putative methyl-CpG binding protein
  • methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylase
  • Mismatch-specific DNA N-glycosylase
  • G/U mismatch glycosylase
  • Methyl-CpG-binding protein MBD4
  • G/T mismatch glycosylase
  • Methyl-CpG-binding endonuclease 1
  • MED1G/5-fluorouracil mismatch glycosylase with biphasic kinetics
  • methyl-CpG binding domain protein 4

Research Areas for MBD4

Find related products by research area and learn more about each of the different research areas below.

Base Excision Repair
Chromatin Research
DNA Repair
Epigenetics

Bioinformatics Tool for MBD4

Discover related pathways, diseases and genes to MBD4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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