MANF Products

Description

MANF is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and promotes cell proliferation. The protein was initially thought to be longer at the N-terminus and to contain an arginine-rich region but transcribed evidence indicates a smaller open reading frame that does not encode the arginine tract. The presence of a specific mutation changing the previously numbered codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. With the protein size correction, this codon is now identified as the initiation codon. [provided by RefSeq]

Bioinformatics

Product By Gene ID	7873
Alternate Names	mesencephalic astrocyte-derived neurotrophic factor ARP arginine-rich, mutated in early stage tumors Protein ARMET Arginine-Rich Protein ARMET

Diseases related to MANF

Discover more about diseases related to MANF.

Parkinson Disease
Neoplasms
Malignant Neoplasms
Ischemia
Endoplasmic Reticulum Stress
Neurodegenerative Disorders
Nervousness
Brain Ischemia
Physiological Stress
Infarction
Carcinoma
Renal Cell Carcinoma
Myocardial Ischemia
Secondary Parkinson Disease
Cerebral Ischemia
Kidney Neoplasm
Brain Injuries
Non-small Cell Lung Carcinoma
Arterial Occlusion
Hypertrophy

Pathways for MANF

View related products by pathway and learn more about each of the pathways below.

Localization
Cell Death
Transport
Secretion
Fertilization
Nuclear Import
Protein Folding
Constitutive Secretory Pathway
Brain Development
Complement Activation
Neurogenesis
Nuclear Transport
Cytokinesis
Mrna Splicing
Translation
Cognition
Exocytosis
Blood Coagulation
Secretory Pathway
Cell Proliferation

PTMs for MANF

Learn more about PTMs related to MANF.

Glycosylation
Biotinylation

Bioinformatics Tool for MANF

Discover related pathways, diseases and genes to MANF. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.