WB, GS, ICC/IF, IHC, IHC-Fr, IHC-P, ChIPHost:
WB, ICC/IF, IHC, IHC-Fr, IHC-PHost:
Hu, Mu, Rt, Ma-OpApplications:
WB, IHC, IHC-P, ChIP, ICC/IF (-)Host:
Applications: WB, ELISA, PA, AP
Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.
|Product By Gene ID
- Pancreatic beta-cell-specific transcriptional activator
- V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
- transcription factor MafA
- Transcription factor RIPE3b1
- v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)
Bioinformatics Tool for MafA
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