MafA Products

Antibodies
MafA Antibody
MafA Antibody
NB400-137
Species: Hu, Mu, Rat
Applications: WB, ChIP, GS, ICC/IF, IHC, IHC-Fr, IHC-P
Host: Rabbit Polyclonal
MafA Antibody
MafA Antibody
NBP1-00121
Species: Hu, Mu, Pm
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
MafA Antibody
MafA Antibody
NBP2-24636
Species: Hu, Mu, Rt, Op, Avian, Chicken
Applications: WB, ICC/IF (-)
Host: Rabbit Polyclonal
Lysates
MafA Overexpression Lysate (N ...
MafA Overexpression Lysate (Native)
NBP2-04601
Applications: WB
Proteins
MafA Partial Recombinant Prot ...
MafA Partial Recombinant Protein
H00389692-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
MafA RNAi
MafA RNAi
H00389692-R01
Species: Hu

Description

Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Mouse
Mouse
Product By Gene ID 389692
Alternate Names
  • RIPE3B1
  • Pancreatic beta-cell-specific transcriptional activator
  • V-maf musculoaponeurotic fibrosarcoma oncogene homolog A
  • hMafA
  • transcription factor MafA
  • RIPE3b1
  • Transcription factor RIPE3b1
  • v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)

Research Areas for MafA

Find related products by research area and learn more about each of the different research areas below.

Diabetes Research
Lipid and Metabolism
Transcription Factors and Regulators

Bioinformatics Tool for MafA

Discover related pathways, diseases and genes to MafA. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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