Lipase A Products

Description

Lipase A, also known as LIPA or Lysosomal acid lipase/cholesteryl ester hydrolase, has a 399 amino acid long isoform that is 45 kDa and a short 343 amino acid isoform that is 39 kDa; lysosome located; is very important for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles, and also in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. This protein is currently being studied for involvement in the following diseases and disorders: cholesteryl ester storage disease, wolman disease, cholesterol, cholesterol ester storage disease, lysosomal storage disease, coronary heart disease, hepatitis c, splenomegaly, hepatitis b, hepatitis, hyperlipidemia, hypercholesterolemia, tuberculosis, obesity atherosclerosis, alzheimer's disease, neisseria meningitides, lipid storage disease, lipodystrophy, pandas, wolman disease, and blepharitis. The LIPA protein has been shown to interact with HIST1H4A, HIST1H4B, HIST1H4C, SOAT1, and HIST1H4E in cholesterol and sphingolipids transport / distribution to the intracellular membrane compartments (normal and CF), steroid biosynthesis, and lysosome pathways.

Bioinformatics

Entrez	3988 Human 16889 Mouse
Uniprot	NM_000235 Human NP_001121077 Human AAH12287 Human AAH12287.1 Human P38571 Human Q9Z0M5 Mouse
Product By Gene ID	3988
Alternate Names	EC 3.1.1 EC 3.1.1.13 Lipase A Sterol esterase lysosomal acid lipase/cholesteryl ester hydrolase Cholesteryl esterase lysosomal acid lipase Acid cholesteryl ester hydrolase LALCESDcholesterol ester hydrolase lipase A, lysosomal acid, cholesterol esterase

Diseases related to Lipase A

Discover more about diseases related to Lipase A.

Wolman Disease
Cholesterol Ester Storage Disease
Storage Disease
Hepatitis
Hepatitis C
Infective Disorder
Carcinoma
Hiv Infections
Neoplasms
Liver Carcinoma
Liver Neoplasms
Alzheimer's Disease
Atherosclerosis
Hepatitis C, Chronic
Liver Diseases
Papillomavirus Infections
Tuberculosis
Fibrosis
Hepatomegaly
Inflammation

Pathways for Lipase A

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Secretion
Pathogenesis
Virulence
Drug Resistance
Transport
Fermentation
Protein Secretion
Cell Growth
Cell Proliferation
Membrane Fusion
Regulation Of Gene Expression
Translation
Biofilm Formation
Cell Adhesion
Cell Migration
Developmental Process
Quorum Sensing
Anaerobic Respiration
Acetate To Acetyl-coa
Response To Paclitaxel

Research Areas for Lipase A

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Lipid and Metabolism

PTMs for Lipase A

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Cleavage
Phosphorylation
Decarboxylation

Bioinformatics Tool for Lipase A

Discover related pathways, diseases and genes to Lipase A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related Lipase A Blog Posts

Check out the latest blog posts on Lipase A.

How do Lipase A and the CD36 Antibody Relate to Each Other Obesity, diabetes and metabolic disorders are dramatically on the increase, linked to disorders such as heart disease, stroke and cancer. To combat this, research groups are studying metabolism at both a cellular and a systemic level. Although we at N...    Read more.

Read more Lipase A related blogs.