Species: Hu, Mu
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Mu
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
Species: Hu
Applications: AC
Description
Lipase A, also known as LIPA or Lysosomal acid lipase/cholesteryl ester hydrolase, has a 399 amino acid long isoform that is 45 kDa and a short 343 amino acid isoform that is 39 kDa; lysosome located; is very important for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles, and also in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. This protein is currently being studied for involvement in the following diseases and disorders: cholesteryl ester storage disease, wolman disease, cholesterol, cholesterol ester storage disease, lysosomal storage disease, coronary heart disease, hepatitis c, splenomegaly, hepatitis b, hepatitis, hyperlipidemia, hypercholesterolemia, tuberculosis, obesity atherosclerosis, alzheimer's disease, neisseria meningitides, lipid storage disease, lipodystrophy, pandas, wolman disease, and blepharitis. The LIPA protein has been shown to interact with HIST1H4A, HIST1H4B, HIST1H4C, SOAT1, and HIST1H4E in cholesterol and sphingolipids transport / distribution to the intracellular membrane compartments (normal and CF), steroid biosynthesis, and lysosome pathways.
Bioinformatics
Entrez |
Human Mouse |
Uniprot |
Human Human Human Human Human Mouse |
Product By Gene ID |
3988 |
Alternate Names |
- EC 3.1.1
- EC 3.1.1.13
- Lipase A
- Sterol esterase
- lysosomal acid lipase/cholesteryl ester hydrolase
- Cholesteryl esterase
- lysosomal acid lipase
- Acid cholesteryl ester hydrolase
- LALCESDcholesterol ester hydrolase
- lipase A, lysosomal acid, cholesterol esterase
|
Research Areas for Lipase A
Find related products by research area and learn more about each of the different research areas below.
Lipid and Metabolism