The Laminins comprise a growing family of disulfide-linked heterotrimers consisting of three genetically distinct polypeptide chains, designated alpha, beta and gamma. A major component of the basal lamina, Laminins play a crucial role in providing a scaffolding upon which tissues are assembled and which serves as a physical barrier separating specialized tissues. During embryogenesis and early development, cells migrate along basement membranes, which are required for the polarization of cells. The beta-2 laminin chain plays a role in melanoma spread, promoting tumor migration along the abluminal surface of vessel, a phenomenon which has been termed extra-vascular migratory metastasis.
![Immunocytochemistry Laminin S/Laminin beta 2 Antibody (C4) [Unconjugated]](http://images.novusbio.com/fullsize2/Laminin_S_MAB2066_Immunocytochemistry__Immunofluorescence_20089.jpg)
