Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IP
Host: Goat Polyclonal
Species: Hu
Applications: WB, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Gp(-), Gt(-), Ha(-), Rb(-), Sh(-)
Applications: ELISA, Flow, IHC, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Mu
Applications: WB, ELISA, ICC/IF, IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC
Host: Goat Polyclonal
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC
Host: Sheep Polyclonal
Description
All five immunoglobulin classes share the same basic four polypeptide chain structure of two heavy-chains and two light chains. There are five heavy chain types, and two light-chain types (Kappa and Lambda) both having a molecular weight of 22.5kDa. Any heavy-chain type can associate with either light-chain type, but on any immunoglobulin molecule both light-chains are of the same type. Kappa and Lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of Kappa to Lambda is 70:30 , the vast majority of which is bound to heavy-chain in immunoglobulin. In normal individuals low levels of free light-chain arepresent in serum (kappa, 1.6-15.2 mg/L; Lambda, 0.4-4.2mg/L), with the occurrence of multiple myeloma or other B-cell malignancies these levels can be greatly elevated and can be found at high levels in the urine (Bence-Jones proteins). This antibody stains only lambda light chain containing cells in human lymphoid tissues.
Bioinformatics
| Entrez |
Human
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
3537 |
| Alternate Names |
- IGLC
- immunoglobulin lambda constant group
|
Research Areas for Lambda Light Chain
Find related products by research area and learn more about each of the different research areas below.
Adaptive ImmunityImmunology
