IRE1 alpha Products

IRE1 alpha Antibody (8D12)
IRE1 alpha Antibody (8D12)
Species: Hu
Applications: WB, ELISA, ICC/IF, PLA
Host: Mouse Monoclonal
Antibody Packs
IRE1 alpha Antibody Pack
IRE1 alpha Antibody Pack
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
IRE1 alpha Knockout HeLa Cell ...
IRE1 alpha Knockout HeLa Cell Lysate
Species: Hu
Applications: WB
IRE1 alpha Blocking Peptide
IRE1 alpha Blocking Peptide
Species: Hu
IRE1 alpha [p Ser724] Blockin ...
IRE1 alpha [p Ser724] Blocking Pep...
Species: Hu
IRE1 alpha Blocking Peptide
IRE1 alpha Blocking Peptide
Species: Hu


IRE-1 alpha is a transmembrane protein that has both intrinsic serine-threonine kinase and endoribonuclease activities. IRE1 alpha is critical for altering gene expression in response to endoplasmic reticulum-based stress signals.

Specifically, IRE1 alpha senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain, which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis. Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER.


Entrez Human
Uniprot Human
Product By Gene ID 2081
Alternate Names
  • IRE 1a
  • FLJ30999
  • EC 2.7.11
  • hIRE1p
  • Ire1-alpha
  • IRE1a
  • serine/threonine-protein kinase/endoribonuclease IRE1
  • Inositol-requiring protein 1
  • protein kinase/endoribonuclease
  • Endoplasmic reticulum-to-nucleus signaling 1
  • ire1-alpha
  • ER to nucleus signalling 1
  • inositol-requiring 1
  • IRE1P
  • IRE1MGC163279
  • MGC163277
  • endoplasmic reticulum to nucleus signaling 1

Research Areas for IRE1 alpha

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Diabetes Research
Lipid and Metabolism
Signal Transduction
Unfolded Protein Response

PTMs for IRE1 alpha

Learn more about PTMs related to IRE1 alpha.


Bioinformatics Tool for IRE1 alpha

Discover related pathways, diseases and genes to IRE1 alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related IRE1 alpha Blog Posts

Check out the latest blog posts on IRE1 alpha.
Analysis of Total & pSer724 IRE1 alpha, the Sensor of ER Stress
Inositol-requiring protein 1/IRE1 alpha (also called Endoplasmic Reticulum to Nucleus Signaling 1/ERN1; predicted mol wt 110 kDa) is a serine-threonine protein kinase/endoribonuclease which plays a highly critical role in unfolded protein response/U...    Read more.
IRE1 alpha dependent apoptotic-signaling pathway
Despite in depth characterization of the role of IRE1 alpha (inositol-requiring enzyme 1 alpha) in activating the unfolded protein response (UPR) in the ER - little is known about the molecular mechanisms by which this ER protein has shown to reg...    Read more.
IRE1 alpha (inositol-requiring enzyme 1 alpha)
The unfolded protein response (UPR) is a eukaryotic cell process that addresses ER stress. UPR is initiated by three ER-localized sensors: PKR-like ER kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1 alpha (...    Read more.
IRE1 alpha and ER Stress: Keys to Disease Progression Pathways
Inositol Requiring Enzyme 1 alpha (IRE1 alpha) is a transmembrane-RNase with an endoplasmic reticulum (ER) luminal sensor domain and cytosolic kinase and ribonuclease domains. IRE1 also plays a central role in the ER stress response (1). In a recent s...    Read more.
Read more IRE1 alpha related blogs.