Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Insig1 is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells.
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. Insig1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
|Product By Gene ID
- insulin-induced gene 1 protein
- INSIG-1 membrane protein
- insulin induced gene 1
Bioinformatics Tool for INSIG-1
Discover related pathways, diseases and genes to INSIG-1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.