INSIG-1 Products


Description

Insig1 is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells.

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. Insig1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 3638
Alternate Names
  • INSIG-1
  • CL6
  • insulin-induced gene 1 protein
  • MGC1405
  • INSIG-1 membrane protein
  • CL-6
  • insulin induced gene 1

Research Areas for INSIG-1

Find related products by research area and learn more about each of the different research areas below.

Cholesterol Metabolism
ER Markers
Lipid and Metabolism
Signal Transduction

Bioinformatics Tool for INSIG-1

Discover related pathways, diseases and genes to INSIG-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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