INSIG-1 Products


Insig1 is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells.

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. Insig1 binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.


Entrez Human
Uniprot Human
Product By Gene ID 3638
Alternate Names
  • INSIG-1
  • CL6
  • insulin-induced gene 1 protein
  • MGC1405
  • INSIG-1 membrane protein
  • CL-6
  • insulin induced gene 1

Research Areas for INSIG-1

Find related products by research area and learn more about each of the different research areas below.

Cholesterol Metabolism
ER Markers
Lipid and Metabolism
Signal Transduction

Bioinformatics Tool for INSIG-1

Discover related pathways, diseases and genes to INSIG-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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