Importin-13 Products

Description

Importin-13 functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13. Expressed in fetal brain, heart, intestine and kidney. Belongs to the importin beta family. Contains 14 HEAT repeats. Contains 1 importin N-terminal domain.

Bioinformatics

Entrez	9670 Human
Uniprot	NM_014652 Human NP_055467 Human NP_055467. Human O94829 Human
Product By Gene ID	9670
Alternate Names	Imp13 IMP13 importin 13 importin-13 Kap13 KAP13 karyopherin 13 Karyopherin-13 KIAA0724karyopherin-13 LGL2 Ran binding protein 13 Ran-binding protein 13 RanBP13 RANBP13late gestation lung 2

Research Areas for Importin-13

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Lipid and Metabolism