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1102-IL) stimulates proliferation in the BaF3 mouse pro‑B cell line co-transfected with human IL‑20 Ra and IL‑20 R beta in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL‑20 (2 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL‑20 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1102). The ND50 is typically 0.1-0.4 µg/mL." class="big_lightbox" target="_blank">
1204-ML) stimulates proliferation in the BaF3 mouse pro‑B cell line co-transfected with human IL‑20 Ra and IL‑20 R beta in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL‑20 (10 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Mouse IL‑20 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1204). The ND50 is typically 0.2-0.6 µg/mL." class="big_lightbox" target="_blank">
1204-ML) stimulates proliferation in the BaF3 mouse pro-B cell line co-transfected with human IL-20 Ra and IL-20 R beta in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Mouse IL-20 (10 ng/mL) is neutralized (green line) by increasing concentrations of Rat Anti-Mouse IL-20 Monoclonal Antibody (Catalog # MAB12043). The ND50 is typically 0.4-4 µg/mL." class="big_lightbox" target="_blank">
The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-lamda. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ralpha and IL-20Rbeta. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ralpha and IL-20Rbeta all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.
![Neutralization IL-20 Antibody (380605) [Unconjugated]](http://images.novusbio.com/images/antibody/IL-20_MAB12043_Block_Neutralize_9014.jpg)
![Sandwich ELISA IL-20 Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-20-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79407-img0001.jpg)
![N/A IL-20 [HRP]](http://images.novusbio.com/fullsize/elisa/DATA_IL20_DL200_ELISA_733.jpg)
![N/A IL-20 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_IL20_DY1204_ELISA_1601.jpg)
![N/A IL-20 [Biotin]](http://images.novusbio.com/fullsize/elisa/DATA_IL20_DY1102_ELISA_1573.jpg)
![N/A IL-20 [HRP]](http://images.novusbio.com/fullsize/elisa/DATA_IL20_DL200_ELISA_734.jpg)
![N/A IL-20 [HRP]](http://images.novusbio.com/fullsize/elisa/IL-20_DL200_ELISA_127.jpg)
