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210-TA), Recombinant Human IL-18/ IL-1F4 stimulates IFN-gamma secretion in the KG-1 human acute myelogenous leukemia cell line in a dose-dependent manner (left-hand graph), as measured by the Human IFN-gamma Quantikine ELISA Kit (Catalog # DIF50C). Under these conditions, IFN-gamma secretion elicited by Recombinant Human IL-18/ IL-1F4 (40 ng/mL) is neutralized (right-hand graph) by increasing concentrations of Mouse Anti-Human IL-18 R beta /IL-1 R7 Monoclonal Antibody (Catalog # MAB1181). The ND50 is typically 0.3-1.0 µg/mL." class="big_lightbox" target="_blank">
MAB0041, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG F(ab')2Secondary Antibody (Catalog # F0102B)." class="big_lightbox" target="_blank">
816-LR) is coated at 0.500 µg/mL (100 µL/well), Biotinylated Recombinant Human IL‑18R beta /IL‑1R7 His-tag Avi-tag Protein (Catalog # AVI11210) binds with an ED50 of 2.00-40.0 ng/mL." class="big_lightbox" target="_blank">
ACPL is encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18.
![Neutralization IL-18 R beta/IL-1 R7/ACPL Antibody (132016) [Unconjugated]](http://images.novusbio.com/images/antibody/IL-18_R_beta_MAB1181_Block_Neutralize_1836.jpg)
![Sandwich ELISA IL-18 R beta/IL-1 R7/ACPL Antibody Pair [HRP]](http://images.novusbio.com/fullsize/IL-18-R-beta-IL-1-R7-ACPL-Antibody-Pair-[HRP]-Sandwich-ELISA-NBP2-79458-img0001.jpg)
![Bioactivity IL-18 R beta/IL-1 R7/ACPL [Unconjugated]](http://images.novusbio.com/fullsize/11210-ap_recombinant-human-il-18-r-beta-il-1-r7-his-tag-protein-cf-bioactivity-296202292432.jpg)
![SDS-Page IL-18 R beta/IL-1 R7/ACPL [Biotin]](http://images.novusbio.com/fullsize/avi118_recombinant-human-il-18-r-beta-il-1-r7-fc-avi-protein-cf-sds-page-612202193540.jpg)
![Binding Activity IL-18 R beta/IL-1 R7/ACPL [Biotin]](http://images.novusbio.com/images/avi11210_recombinant-human-il-18-r-beta-il-1-r7-his-avi-protein-cf-binding-activity-309202215621.jpg)
![Western Blot IL-18 R beta/IL-1 R7/ACPL Antibody (132016) [Unconjugated]](http://images.novusbio.com/fullsize/mab1181_human-il-18-r-beta-il-1-r7-mab-clone-132016-41202412505310.jpg)
![Flow Cytometry IL-18 R beta/IL-1 R7/ACPL Antibody (132029) [Unconjugated]](http://images.novusbio.com/images/antibody/IL-18_R_beta_MAB118_Flow_Cytometry_8325.jpg)
![SDS-Page IL-18 R beta/IL-1 R7/ACPL [Unconjugated]](http://images.novusbio.com/fullsize/11210-ap_recombinant-human-il-18-r-beta-il-1-r7-his-tag-protein-cf-sds-page-29620229528.jpg)
![SDS-Page IL-18 R beta/IL-1 R7/ACPL [Biotin]](http://images.novusbio.com/fullsize/avi11210_recombinant-human-il-18-r-beta-il-1-r7-his-avi-protein-cf-sds-page-14920228145.jpg)
