IKK beta Products

Antibodies
IKK beta Antibody
IKK beta Antibody
NB600-477
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
IKK beta Antibody Pair
IKK beta Antibody Pair
H00000334-AP11
Species: Hu
Applications: S-ELISA
Lysates
IKK beta Overexpression Lysat ...
IKK beta Overexpression Lysate (De...
H00003551-T01
Species: Hu
Applications: WB
IKK beta Overexpression Lysat ...
IKK beta Overexpression Lysate (Na...
NBP2-10983
Applications: WB
Proteins
IKK beta Recombinant Protein ...
IKK beta Recombinant Protein Antigen
NBP1-87699PEP
Species: Hu
Applications: AC
Recombinant Human IKK beta Pr ...
Recombinant Human IKK beta Protein
P4703
Species: Hu
Applications: Func, PAGE
IKK beta Peptide
IKK beta Peptide
NB600-477PEP
Species: Hu
Applications: AC
RNAi
IKK beta RNAi
IKK beta RNAi
H00003551-R03
Species: Hu
Applications: RNAi, RNAi SP

Description

NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (1). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) (6) and MAP kinase kinase kinase-1 (MEKK1) (7), respectively. Recent studies have shown that IKK2/b, not IKK1/a, is the target proinflammatory stimuli (9). Targeted disruption of IKK2/b gene in mice also results in extensive liver damage from apotopsis and death as embryo (9).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 3551
Alternate Names
  • EC 2.7.11
  • I-kappa-B-kinase beta
  • IkBKB
  • I-kappa-B kinase 2
  • inhibitor of nuclear factor kappa-B kinase subunit beta
  • IKK-B
  • MGC131801
  • Nuclear factor NF-kappa-B inhibitor kinase beta
  • IKKBFLJ40509
  • IKK2FLJ38368
  • IKK-betaFLJ36218
  • NFKBIKBFLJ33771
  • EC 2.7.11.10
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

Research Areas for IKK beta

Find related products by research area and learn more about each of the different research areas below.

Cancer
Immunology
Innate Immunity
mTOR Pathway
Phospho-Specific
Protein Kinase

Bioinformatics Tool for IKK beta

Discover related pathways, diseases and genes to IKK beta. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related IKK beta Blog Posts

Check out the latest blog posts on IKK beta.
Regulating Immune Response Pathways with IKK beta
IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f...    Read more.
IKK alpha: Roles in Development, B-cell Survival and ESC Differentiation
Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK1 alpha) is a serine/threonine kinase that forms a complex with IKK beta and NEMO. It plays an essential role in embryonic skin development. Mice with low levels of IKKa show an increase in...    Read more.
Read more IKK beta related blogs.