IKK beta Products

Description

NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus (1). External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated (2). IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g (3-5). IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) (6) and MAP kinase kinase kinase-1 (MEKK1) (7), respectively. Recent studies have shown that IKK2/b, not IKK1/a, is the target proinflammatory stimuli (9). Targeted disruption of IKK2/b gene in mice also results in extensive liver damage from apotopsis and death as embryo (9).

Bioinformatics

Entrez	16150 Mouse 3551 Human 84351 Rat
Uniprot	AAH06231 Human AAH06231.1 Human AF080158 Human IKKB_HUMAN Human NM_001556 Human NP_001547 Human NP_001547.1 Human O14920 Human
Product By Gene ID	3551
Alternate Names	EC 2.7.11 EC 2.7.11.10 I-kappa-B kinase 2 I-kappa-B-kinase beta IkBKB IKK2FLJ38368 IKK-B IKK-betaFLJ36218 IKKBFLJ40509 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta inhibitor of nuclear factor kappa-B kinase subunit beta MGC131801 NFKBIKBFLJ33771 Nuclear factor NF-kappa-B inhibitor kinase beta

Research Areas for IKK beta

Find related products by research area and learn more about each of the different research areas below.

Cancer
Immunology
Innate Immunity
mTOR Pathway
Phospho-Specific
Protein Kinase

Related IKK beta Blog Posts

Check out the latest blog posts on IKK beta.

IKK alpha: Roles in Development, B-cell Survival and ESC Differentiation Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK1 alpha) is a serine/threonine kinase that forms a complex with IKK beta and NEMO. It plays an essential role in embryonic skin development. Mice with low levels of IKKa show an increase in ...    Read more.

Regulating Immune Response Pathways with IKK beta IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f...    Read more.

Read more IKK beta related blogs.