IGSF2/CD101 Products

Description

CD101 is a disulfide-linked homodimeric type 1 glycoprotein. The peptide is comprised of 7 extracellular V-type IgSF domains. CD101 is highly expressed on monocytes, granulocytes, mucosal T cells, and on activated peripheral blood T cells. Expression is weak on resting T and B and NK cells, absent from platelets and weak or absent from most hematopoietic cell lines. CD101 is thought to play a co-stimulatory role in TCR/CD3-mediated T cell activation. Monoclonal antibodies against CD101 inhibit allogeneic T cell responses. Studies suggest that CD101 plays a major role in the activation of T cells by skin dendritic cells.

Bioinformatics

Entrez	9398 Human
Uniprot	NP_004249 Human Q93033 Human
Product By Gene ID	9398
Alternate Names	IGSF2 CD101 antigen EWI-101 IgSF2 Glu-Trp-Ile EWI motif-containing protein 101 EWI101 Cell surface glycoprotein V7 leukocyte surface protein member 2 CD101 molecule

Diseases related to IGSF2/CD101

Discover more about diseases related to IGSF2/CD101.

Diabetes Mellitus
Diabetes Mellitus, Insulin-dependent
Autoimmune Reaction
Autoimmunity
Autoimmune Diseases
Sclerosis
Liver Diseases
Hepatitis, Autoimmune
Inflammatory Bowel Diseases
Lung Diseases
Immunologic Tolerance
Intestinal Diseases
Lung Diseases, Interstitial
Histiocytosis
Malignant Neoplasms
Neoplasms
Histiocytosis, Langerhans-cell
Pancreatic Neoplasm
Malignant Neoplasm Of Pancreas
Diabetes, Autoimmune

Pathways for IGSF2/CD101

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Cell Activation
T Cell Activation
Bioluminescence
Cell Proliferation
Chemotaxis
Cell Motility
T Cell Proliferation
Glycosylation
Localization
Secretion

PTMs for IGSF2/CD101

Learn more about PTMs related to IGSF2/CD101.

Phosphorylation
Dephosphorylation

Bioinformatics Tool for IGSF2/CD101

Discover related pathways, diseases and genes to IGSF2/CD101. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.