HTRA2/Omi Products

Description

HtrA2 (Omi) is a serine protease that plays a significant role in programmed cell death, or apoptosis. Localized to the intermembrane space of the mitochondria, HtrA2 exists predominantly as two isoforms (1). In response to cellular stress signals, HtrA2 is released into the cytosol. One way that HtrA2 induces apoptosis is by binding to BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), and thereby inhibiting their caspase-inhibitory activity (2,3).

Bioinformatics

Entrez	27429 Human 297376 Rat 64704 Mouse
Uniprot	AAB94569 Human AAH00096 Human BAF84666 Human NP_037379 Human O43464 Human
Product By Gene ID	27429
Alternate Names	High temperature requirement protein A2 HtrA serine peptidase 2 HtrA2 HtrA-like serine protease OMIOmi stress-regulated endoprotease PARK13EC 3.4.21.108 PRSS25serine, 25 Serine protease 25 serine protease HTRA2, mitochondrial Serine proteinase OMI

Research Areas for HTRA2/Omi

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer