Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: Enzyme Activity
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
HtrA2 (Omi) is a serine protease that plays a significant role in programmed cell death, or apoptosis. Localized to the intermembrane space of the mitochondria, HtrA2 exists predominantly as two isoforms (1). In response to cellular stress signals, HtrA2 is released into the cytosol. One way that HtrA2 induces apoptosis is by binding to BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), and thereby inhibiting their caspase-inhibitory activity (2,3).
Bioinformatics
| Entrez |
Human
Rat
Mouse
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
27429 |
| Alternate Names |
- High temperature requirement protein A2
- HtrA serine peptidase 2
- HtrA2
- HtrA-like serine protease
- OMIOmi stress-regulated endoprotease
- PARK13EC 3.4.21.108
- PRSS25serine, 25
- Serine protease 25
- serine protease HTRA2, mitochondrial
- Serine proteinase OMI
|
Research Areas for HTRA2/Omi
Find related products by research area and learn more about each of the different research areas below.
ApoptosisCancer
![Western Blot HTRA2/Omi Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/HTRA2_AF1458_Western_Blot_5114.jpg)
![Immunocytochemistry HTRA2/Omi Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/HTRA2_AF1458_Immunocytochemistry_9924.jpg)
![Simple Western HTRA2/Omi Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/16328.jpg)
![Western Blot HTRA2/Omi Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1458_human-mouse-rat-htra2-omi-affinity-purified-polyclonal-ab-8220249504633.jpg)
![Western Blot HTRA2/Omi Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1458_human-mouse-rat-htra2-omi-affinity-purified-polyclonal-ab-822024951145.jpg)
![Western Blot HTRA2/Omi Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af1458_human-mouse-rat-htra2-omi-affinity-purified-polyclonal-ab-44202415425018.jpg)
![Western Blot HTRA2/Omi Antibody (229926) [Unconjugated]](http://images.novusbio.com/fullsize2/HTRA2_MAB1458_Western_Blot_5969.jpg)
![Immunocytochemistry HTRA2/Omi Antibody (229926) [Unconjugated]](http://images.novusbio.com/fullsize2/mab1458_human-htra2-omi-mab-clone-229926-immunocytochemistry-186202184143.jpg)
