HRD1 Products

Description

HRD1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of HRD1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. HRD1 is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. It has been reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its anti-apoptotic effects. HRD1 contains one ring-type zinc finger.

Bioinformatics

Product By Gene ID	84447
Alternate Names	E3 ubiquitin-protein ligase synoviolin EC 6.3.2 HRD1EC 6.3.2.- KIAA1810Synovial apoptosis inhibitor 1 MGC40372 synovial apoptosis inhibitor 1, synoviolin

Research Areas for HRD1

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Apoptosis

Related HRD1 Blog Posts

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OS9: Taking proteins to the ER finish line The OS9 protein is a lectin/glycoprotein that maintains endoplasmic reticulum (ER) quality control and ER-associated degradation (the so-called ERAD pathway) of newly synthesized proteins. It is essential for the recognition of terminally misfolded no...    Read more.

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