Hematopoietic Prostaglandin D Synthase/HPGDS Products

Description

Prostaglandin D synthase catalyzes the isomerization of PGH2 to produce PGD2. Prostaglandin D synthase induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGD synthase have been identified, namely the lipocalin type enzyme (b-trace) and the hematopoietic enzyme. Lipocalin type prostaglandin D synthase is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as b-trace, which is a major protein in human cerebrospinal fluid. Hematopoietic prostaglandin D synthase is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes. This enzyme, which requires glutathione for activity, belongs to the sigma-class of glutathione-S-transferases.

Bioinformatics

Entrez	27306 Human
Uniprot	NM_014485 Human NP_055300.1 Human O60760 Human
Product By Gene ID	27306
Alternate Names	EC 2.5.1.18 EC 5.3.99.2 glutathione S-transferase sigma Glutathione S-transferase Glutathione-dependent PGD synthase Glutathione-requiring prostaglandin D synthase GST class-sigma GSTShematopoietic prostaglandin D2 synthase hematopoietic prostaglandin D synthase H-PGDS PGDSglutathione-dependent PGD synthetase Prostaglandin-H2 D-isomerase PTGDS2