GTF2IRD1 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID

9569

Alternate Names

BEN CREAM1 general transcription factor II-I repeat domain-containing protein 1 General transcription factor III GTF2I repeat domain containing 1 GTF2I repeat domain-containing protein 1 GTF3GTF2I repeat domain-containing 1 hMusTRD1alpha1 muscle TFII-I repeat domain-containing protein 1 alpha 1 Muscle TFII-I repeat domain-containing protein 1 MusTRD1 MusTRD1/BEN MUSTRD1general transcription factor 3 RBAP2WBSCR12binding factor for early enhancer Slow-muscle-fiber enhancer-binding protein USE B1-binding protein WBS WBSCR11 Williams-Beuren syndrome chromosomal region 11 protein Williams-Beuren syndrome chromosomal region 12 protein Williams-Beuren syndrome chromosome region 11