Granulin Products

Description

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Bioinformatics

Entrez	2896 Human
Uniprot	NM_002087 Human NP_002078 Human NP_002078.1 Human P28798 Mouse P28799 Human
Product By Gene ID	2896
Alternate Names	acrogranin GEP GP88 granulin granulin-epithelin granulins PC cell-derived growth factor PCDGF PEPI PGRN proepithelin Proepithelin progranulin

Research Areas for Granulin

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication