gp96/HSP90B1/GRP94 Products

Description

Heat shock protein (HSP) molecular chaperones are environmental stressinducible gene products. The human HSP 90 family includes 17 genes that fall into four classes: HSP90AA, HSP90AB, HSP90B and TRAP. HSP 90 family members guide the normal folding, intracellular disposition and proteolytic turnover of many key regulators of cell growth, differentiation and survival. HSP 90alpha, also designated HSP90A, HSP 86 and LPS-associated protein 2 (LAP2), is a cytosolic enhancer of inducible nitric-oxide synthase (iNOS), with chaperone activity that is important for the transcriptional activity of p53. HSP 90beta, also designated HSP90B, HSP 84 and HSPC2, is a cytosolic protein that participates in signaling pathways with PKC episilon to protect cells from external damage, particularly in heat shock-mediated events. GRP 94, also known as tumor rejection antigen 1 (TRA1), ECGP and GP96, localizes to the ER, is highly expressed in BGC-823 human gastric carcinoma cells and is upregulated in human endothelial cells in response to hypoxia by HIF-1. TRAP-1 (TNF receptor-associated protein-1), also designated HSP 75, is a mitochondrial matrix component that plays a role in the induction of apoptosis in response to reactive oxygen species.

Bioinformatics

Product By Gene ID	7184
Alternate Names	94 kDa glucose-regulated protein ECGP Endoplasmin endothelial cell (HBMEC) glycoprotein glucose regulated protein, 94 kDa gp96 GP96ECGP Grp94 GRP-94 GRP94gp96 homolog Heat shock protein 90 kDa beta member 1 heat shock protein 90kDa beta (Grp94), member 1 HSP90B1 TRA1endoplasmin tumor rejection antigen (gp96) 1 Tumor rejection antigen 1 Tumor rejection antigen-1 (gp96)

Research Areas for gp96/HSP90B1/GRP94

Find related products by research area and learn more about each of the different research areas below.

Cancer
ER Markers
Golgi Apparatus Markers
Hypoxia
Membrane Trafficking and Chaperones