gp96/HSP90B1/GRP94 Products

Description

Glucose-regulated protein 94, also known as Grp94 or gp96, is an abundant resident endoplasmic reticulum (ER) lumenal stress protein which together with cytosolic Hsp90 belongs to the Hsp90 family of molecular chaperones. Grp94 and other resident soluble proteins of the ER such as members of the Ca(2+) binding protein subfamily (CaBP), CaBPI and CaBP2 as well as calreticulin, possess the COOH-terminal tetrapeptide Lys-Asp-Glu-Leu (KDEL) which is a sorting signal that is thought to lead to the retention of these proteins in the pre-Golgi compartments (1). Grp94 expression is upregulated by stress conditions such as lucose starvation and heat shock, which promote protein misfolding or unfolding (2). In addition to a homeostatic role in protein folding and assembly, Grp94 can function in the intracellular trafficking of peptides from the extracellular space to the MHC class I antigen processing pathway of antigen presentation cells (3,4). Grp94 and Hsp90 share high sequence identity and presumably identical adenosine nucleotide-dependent modes of regulation. Earlier data suggests that Hsp90 and Grp94 may differ in their nucleotide binding properties. The N-terminal domain of eukaryotic Hsp90 proteins contains a conserved adenosine nucleotide binding pocket which also serves as the inding site for the Hsp90 inhibitors geldanamycin and radicicol. However, the molecular basis for adenosine nucleotide-dependent regulation of Grp94remains to be established. Recent data has entified a ligand dependent regulation of Grp94 function and suggest a model whereby Grp94 function is regulated through a ligand-dependent conversion of Grp94 from an inactive to an active conformation (5, 6).

Bioinformatics

Entrez	22027 Mouse 362862 Rat 374163 Chicken 7184 Human
Uniprot	AAH09195 Human AAH09195.1 Human EAW97723 Human NM_003299 Human NP_003290 Human P08110 Chicken P14625 Human
Product By Gene ID	7184
Alternate Names	94 kDa glucose-regulated protein endothelial cell (HBMEC) glycoprotein glucose regulated protein, 94 kDa GP96ECGP GRP-94 GRP94gp96 homolog Heat shock protein 90 kDa beta member 1 heat shock protein 90kDa beta (Grp94), member 1 TRA1endoplasmin tumor rejection antigen (gp96) 1 Tumor rejection antigen 1 Tumor rejection antigen-1 (gp96)

Research Areas for gp96/HSP90B1/GRP94

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cellular Markers
ER Markers
Golgi Apparatus Markers
Hypoxia
Membrane Trafficking and Chaperones
Phospho-Specific