GCLC Products

Antibodies
GCLC Antibody (3H1)
GCLC Antibody (3H1)
H00002729-M01
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF
Host: Mouse Monoclonal
GCLC Antibody
GCLC Antibody
NBP1-49762
Species: Hu, Mu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
GCLC Antibody
GCLC Antibody
NBP1-81840
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Lysates
GCLC Overexpression Lysate (N ...
GCLC Overexpression Lysate (Native)
NBL1-11011
Applications: WB
Proteins
GCLC Recombinant Protein
GCLC Recombinant Protein
H00002729-P01
Species: Hu
Applications: WB, ELISA, PA
GCLC Partial Recombinant Prot ...
GCLC Partial Recombinant Protein
H00002729-Q01
Species: Hu
Applications: WB, ELISA, PA
GCLC Recombinant Protein Anti ...
GCLC Recombinant Protein Antigen
NBP1-81840PEP
Species: Hu
Applications: AC
RNAi
GCLC RNAi
GCLC RNAi
H00002729-R01
Species: Hu

Description

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Rat
Product By Gene ID 2729
Alternate Names
  • GCS heavy chain
  • Gamma-ECS
  • GLCL
  • glutamate--cysteine ligase catalytic subunit
  • Gamma-glutamylcysteine synthetase
  • gamma-ECS
  • GCS
  • GLCLCGCL
  • EC 6.3.2.2
  • glutamate-cysteine ligase, catalytic subunit

Research Areas for GCLC

Find related products by research area and learn more about each of the different research areas below.

Cell Biology
Lipid and Metabolism

Bioinformatics Tool for GCLC

Discover related pathways, diseases and genes to GCLC. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related GCLC Blog Posts

Check out the latest blog posts on GCLC.
The effects of ethanol consumption on glutamate production and xCT
xCT is a sodium independent glutamate transporter that regulates the exchange of extracellular l-cystine and intracellular l-glutamate across the plasma membrane. This process is critical to glutathione production and protection from subsequent ox...    Read more.
Read more GCLC related blogs.