GALE Products

Antibodies
Antibody Pairs
GALE Antibody Pair
GALE Antibody Pair
H00002582-PW1
Species: Hu
Applications: WB, IP
Lysates
GALE Overexpression Lysate
GALE Overexpression Lysate
NBL1-10947
Species: Hu
Applications: WB
GALE Overexpression Lysate
GALE Overexpression Lysate
NBL1-10946
Species: Hu
Applications: WB
GALE Overexpression Lysate
GALE Overexpression Lysate
NBP2-09454
Species: Hu
Applications: WB
Proteins
GALE Recombinant Protein Anti ...
GALE Recombinant Protein Antigen
NBP1-87066PEP
Species: Hu
Applications: AC
Recombinant Human GALE Protei ...
Recombinant Human GALE Protein
NBP1-45279
Species: Hu
Applications: PAGE

Description

GALE encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 2582
Alternate Names
  • EC 5.1.3
  • FLJ97302
  • Galactowaldenase
  • FLJ95174
  • UDP-glucose 4-epimerase
  • EC 5.1.3.2
  • UDP galactose-4'-epimerase
  • UDP-galactose 4-epimerase
  • short chain dehydrogenase/reductase family 1E, member 1
  • UDP-
  • UDP-galactose-4-epimerase

Research Areas for GALE

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism

Bioinformatics Tool for GALE

Discover related pathways, diseases and genes to GALE. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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