GAB2 Products

Description

This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq]

Bioinformatics

Entrez	9846 Human
Uniprot	NP_536739.1 Human
Product By Gene ID	9846
Alternate Names	GAB2 GRB2-associated binding protein 2 GRB2-associated-binding protein 2 Growth factor receptor bound protein 2-associated protein 2 KIAA0571GRB2-associated binder 2 p100 pp100

Research Areas for GAB2

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Cancer

Related GAB2 Blog Posts

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CD19: An Undoubted Biomarker for B Cells CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t...    Read more.

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