Host: Sheep Polyclonal
Applications: WB, ELISA, PA
Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors; Gab2 acts as a docking protein for several SH2-containing proteins (1-3). Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC (4-5).
|Product By Gene ID
- GRB2-associated-binding protein 2
- Growth factor receptor bound protein 2-associated protein 2
- KIAA0571GRB2-associated binder 2
- GRB2-associated binding protein 2
Research Areas for GAB2
Find related products by research area and learn more about each of the different research areas below.Cancer
Bioinformatics Tool for GAB2
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