G protein alpha Products

Description

G protein alpha has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contains a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. [provided by RefSeq]

Bioinformatics

Entrez	14683 Mouse 24896 Rat 2778 Human
Uniprot	NM_000516 Human NM_016592 Human NP_000507 Human NP_000507.1 Human NP_536351 Human P63092 Human
Product By Gene ID	2778
Alternate Names	Adenylate cyclase-stimulating G alpha protein AHO Alternative gene product encoded by XL-exon Extra large alphas protein GNAS complex locus GNAS1GSA GNASXL GPSAC20orf45 GSP guanine nucleotide binding protein (G protein), alpha stimulating activitypolypeptide 1 guanine nucleotide regulatory protein guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas MGC33735 NESP NESP55 neuroendocrine secretory protein PHP1A PHP1B PHP1C POH protein ALEX SCG6 secretogranin VI XLalphas

Research Areas for G protein alpha

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Signal Transduction