Furin Products

Antibodies
Furin Antibody
Furin Antibody
NB100-1903
Species: Hu, Mu, Rt, Po, Ca, Ha, Pm
Applications: WB, B/N, Flow, ICC/IF, IHC-P, IP
Host: Rabbit Polyclonal
Furin Antibody
Furin Antibody
NBP2-24687
Species: Hu, Mu, Rt, Bv, Ca, Eq, Pm
Applications: IHC-P
Host: Rabbit Polyclonal
Furin Antibody [Unconjugated] ...
Furin Antibody [Unconjugated]
AF1503
Species: Hu
Applications: WB, IP
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
Lysates
Furin Overexpression Lysate ( ...
Furin Overexpression Lysate (Native)
NBL1-10860
Applications: WB
Proteins
Furin Recombinant Protein
Furin Recombinant Protein
NBP2-52031
Species: Hu
Applications: PAGE
RNAi
Furin RNAi
Furin RNAi
H00005045-R01
Species: Hu

Description

Furin is a membrane-associated, calcium-dependent, serine protease that belongs to the subtilisin-like prohormone convertase (PC) family. Members of this family of cellular enzymes cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. Furin and other PC family members share structural similarities which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. Furin is the only known PC to possess a transmembrane domain. Cleavage of target proteins occurs at the carboxyl-terminus of the furin consensus sequence, RX(K/R)R. It has been shown that the acidic peptide sequence, C771PSDSEEDEG780, localizes furin to the trans-Golgi-network. Phosphorylation of serine residues within this region modulates intracellular routing of Furin protein. An additional signaling domain includes the tetrapeptide sequence, Y759KGL762, which directs internalization from the cell surface.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 5045
Alternate Names
  • EC 3.4.21.75
  • EC 3.4.21
  • Paired basic amino acid residue-cleaving enzyme
  • proprotein convertase subtilisin/kexin type 3
  • Dibasic-processing enzyme
  • furin, membrane associated receptor protein
  • SPC1
  • PCSK3furin
  • PACEFES upstream region
  • FURdibasic processing enzyme
  • paired basic amino acid cleaving enzyme (furin, membrane associated receptorprotein)
  • furin (paired basic amino acid cleaving enzyme)

Research Areas for Furin

Find related products by research area and learn more about each of the different research areas below.

Golgi Apparatus Markers
Stem Cell Signaling Pathway

Bioinformatics Tool for Furin

Discover related pathways, diseases and genes to Furin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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