Species: Hu, Mu, Rt
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Applications: WB, Flow, ICC/IF
Host: Mouse Monoclonal
Applications: WB, ELISA, PA, AP
Applications: WB, ELISA, PA, PAGE, AP
Belonging to the FBXO31 family, F-box only protein 31 (FBXO31) is a component of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex and is involved in cyclin binding. At the protein level, FBXO31 plays a central role in G1 arrest following DNA damage. More specifically, these F-box proteins interact with SKP1 and recognize phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, thus resulting in G1 arrest. Diseases associated with FBXO31 include breast cancer, mast cell neoplasm, esophagitis and carcinoma.
|Product By Gene ID
- SCF ubiquitin ligase specificity factor
- putative breast cancer tumor-suppressor
- F-box only protein 31
- F-box protein 31
Bioinformatics Tool for FBXO31
Discover related pathways, diseases and genes to FBXO31. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.