Species: Hu, Mu
Applications: WB, ICC/IF, IP
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: WB, ICC/IF
Host: Mouse Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: AC
Description
Belonging to the FBXO31 family, F-box only protein 31 (FBXO31) is a component of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex and is involved in cyclin binding. At the protein level, FBXO31 plays a central role in G1 arrest following DNA damage. More specifically, these F-box proteins interact with SKP1 and recognize phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, thus resulting in G1 arrest. Diseases associated with FBXO31 include breast cancer, mast cell neoplasm, esophagitis and carcinoma.
Bioinformatics
| Entrez |
Rat
Mouse
Human
|
| Uniprot |
Human
Human
Human
Human
Human
|
| Product By Gene ID |
79791 |
| Alternate Names |
- DKFZp434B027
- F-box only protein 31
- F-box protein 31
- FBX14DKFZp434J1815
- FBX31
- Fbx31
- FBXO14FLJ22477
- MGC15419
- MGC9527
- pp2386
- putative breast cancer tumor-suppressor
- SCF ubiquitin ligase specificity factor
|
