Factor XII heavy chain Products

Description

The F12 gene encodes a 615 amino acid long, 67 kDA serum glycoprotein coagulation factor XII that is eventually cleaved into four chains. Factor XII functions in the initiation of blood coagulation, fibrinolysis, as well as in the creation of bradykinin and angiotension. F12 participates in cell adhesion plasmin signaling, blood coagulation signaling pathways, MSP-RON signaling, intrinsic prothrombin activation pathways, and blood clotting cascades. It interacts with Genes CD93, MMP13, EPAS1, APP, and KLKB1. Defects in F12 lead to factor Xii deficiency (Hageman factor deficiency) as well as hereditary angioedema type 3 (estrogen-related HAE). F12 is also associated with blood clots, acute myocardial infarction, thrombosis, spastic paraplegia, angiodema, retinal vein occlusion, arterial calcification, heart disease, C1 inhibitor deficiency, hemorrhagic disease, and acalculous cholecystitis.

Bioinformatics

Entrez	2161 Human
Uniprot	AAH12390 Human AAH12390.1 Human P00748 Human
Product By Gene ID	2161
Alternate Names	beta-factor XIIa part 1 coagulation factor XII (Hageman factor) coagulation factor XII coagulation factor XIIa heavy chain coagulation factor XIIa light chain EC 3.4.21 EC 3.4.21.38 HAE3 HAEX HAFbeta-factor XIIa part 2 Hageman factor

Diseases related to Factor XII heavy chain

Discover more about diseases related to Factor XII heavy chain.

Neoplasms
Malignant Neoplasms
Cholera
Tissue Adhesions
Carcinoma
Pituitary Diseases
Adenocarcinoma
Thrombosis
Cell Transformation, Neoplastic
Immunologic Deficiency Syndromes
Hyperplasia
Diabetes Mellitus
Nervousness
Mammary Neoplasms
Malignant Paraganglionic Neoplasm
Leukemia
Melanoma
Angioedema
Angioedemas, Hereditary
Corneal Diseases

Pathways for Factor XII heavy chain

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Cell Growth
Cell Proliferation
Secretion
Coagulation
Regeneration
Cell Cycle
Cell Death
Cell Differentiation
Transport
Pathogenesis
Localization
Wound Healing
Cell Adhesion
Spermatogenesis
Cell Division
Cell Migration
Embryo Development
Reverse Transcription
Contact Inhibition
Fermentation

PTMs for Factor XII heavy chain

Learn more about PTMs related to Factor XII heavy chain.

Cleavage
Phosphorylation
Oxidation
Reduction
Hydroxylation
Glycosylation
Demethylation
Ribosylation
Biotinylation
Nitration
Deacetylation
Methylation
Deglycosylation

Bioinformatics Tool for Factor XII heavy chain

Discover related pathways, diseases and genes to Factor XII heavy chain. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.