F-Spondin/SPON1 Products

Description

SPON1 is a member of a subgroup of the thrombospondin type 1 (TSR) class molecules, defined by two domains of homology, the FS1/FS2 and TSR domains. The TSRs of SPON1 proteins are typical of class 2 TSRs. SPON1, which is similar to thrombospondin, is a extracellular matrix attached molecule that promotes neurite outgrowth and inhibits angiogenesis. Analysis of gain and loss of function experiments reveal that SPON1 is required for accurate pathfinding of embryonic axons, and plays a dual role in patterning axonal trajectories. It promotes the outgrowth of commissural and inhibits the outgrowth of motor axons, and has also been implicated in inflammatory processes in the nervous system.

Bioinformatics

Entrez	104062 Mouse 10418 Human 64456 Rat
Uniprot	NM_006108 Human NP_006099 Human
Product By Gene ID	10418
Alternate Names	F-spondin f-spondin KIAA0762VSGP/F-spondin MGC10724 spondin 1, (f-spondin) extracellular matrix protein spondin 1, extracellular matrix protein spondin-1 Vascular smooth muscle cell growth-promoting factor VSGP

Research Areas for F-Spondin/SPON1

Find related products by research area and learn more about each of the different research areas below.

Neuroscience