ENPP-2/Autotaxin Products

Description

The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]. Transcript Variant: This variant (2) lacks an in-frame coding exon in the middle region, compared to variant 1, resulting in a shorter protein (isoform 2, also known as beta), compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID	5168
Alternate Names	ATX ATXFLJ26803 ATX-X Autotaxin autotaxin-t EC 3.1.4.39 ectonucleotide pyrophosphatase/phosphodiesterase 2 ectonucleotide pyrophosphatase/phosphodiesterase family member 2 E-NPP 2 ENPP2 ENPP-2 Extracellular lysophospholipase D Lysophosphatidic Acid LysoPLD NPP2 PD-IALPHA PDNP2 PDNP2NPP2 phosphodiesterase I/nucleotide pyrophosphatase 2 plasma lysophospholipase D

Research Areas for ENPP-2/Autotaxin

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Cardiovascular Biology