EGLN3/PHD3 Products

Antibodies
EGLN3/PHD3 Antibody
EGLN3/PHD3 Antibody
NB100-303
Species: Hu, Mu, Pm, Rat
Applications: WB, Simple Western, ChIP, ICC/IF, IHC-P, IP
Host: Rabbit Polyclonal
EGLN3/PHD3 Antibody (EG188e/d ...
EGLN3/PHD3 Antibody (EG188e/d5)
NBP1-30440
Species: Hu, Rt, Pm, Bovine, Mouse
Applications: WB, Simple Western, IHC, IHC-P
Host: Mouse Monoclonal
Lysates
EGLN3/PHD3 Overexpression Lys ...
EGLN3/PHD3 Overexpression Lysate (...
NBL1-10156
Species: Hu
Applications: WB
EGLN3/PHD3 Overexpression Lys ...
EGLN3/PHD3 Overexpression Lysate (...
H00112399-T01
Species: Hu
Applications: WB
Proteins
EGLN3/PHD3 Partial Recombinan ...
EGLN3/PHD3 Partial Recombinant Pro...
H00112399-Q01
Species: Hu
Applications: WB, ELISA, PA
EGLN3/PHD3 Recombinant Protei ...
EGLN3/PHD3 Recombinant Protein
H00112399-P01
Species: Hu
Applications: WB, ELISA, PA
EGLN3/PHD3 Recombinant Protei ...
EGLN3/PHD3 Recombinant Protein
NBP2-53035
Species: Hu
Applications: PAGE

Description

HIF prolyl hydroxylase 3 (HPH-3; PHD3; EGLN3) catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins, hydroxylates HIF-1 alpha at Pro-564, and also hydroxylates HIF-2 alpha. PHD3 functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. EGLN3 may play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. HIF prolyl hydroxylase 3 promotes cell death through a caspase-dependent mechanism.

Bioinformatics

Uniprot Human
Human
Human
Human
Product By Gene ID 112399
Alternate Names
  • FLJ21620
  • EC 1.14.11
  • HIF-prolyl hydroxylase 3
  • EC 1.14.11.-
  • HPH-3
  • HIF prolyl hydroxylase 3
  • HPH-1
  • egl nine-like protein 3 isoform
  • HIF-PH3
  • egl nine homolog 3
  • Prolyl hydroxylase domain-containing protein 3
  • MGC125999
  • Hypoxia-inducible factor prolyl hydroxylase 3
  • HIFPH3 MGC125998
  • PHD3
  • EGL nine (C.elegans) homolog 3
  • egl nine homolog 3 (C. elegans)

Research Areas for EGLN3/PHD3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Chromatin Research
Hypoxia

PTMs for EGLN3/PHD3

Learn more about PTMs related to EGLN3/PHD3.

Hydroxylation
Ubiquitination
Phosphorylation
Methylation
Demethylation
Acetylation

Bioinformatics Tool for EGLN3/PHD3

Discover related pathways, diseases and genes to EGLN3/PHD3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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